The Wicomico Presbyterian Church Collection contains various materials concerning the Wicomico Presbyterian Church and related congregations, however, it does not represent a complete history of the Wicomico Presbyterian Church. All materials in this collection have been photocopied, therefore, it does not contain any original documents, photographs or papers. Information is given about a variety of topics including Presbyterian history in Wicomico County, church pastors and the women of the Wicomico Presbyterian Church's Women's Association. The collection spans from the 18th Century, with copies of documents and transcriptions, through the 1950's, with papers concerning church renovation and weekly church bulletins. Select budget information and correspondence from the early to mid 20th Century can also be viewed. The Wicomico Presbyterian Church celebrated its 250th Anniversary in 1933, commemorating founder Francis Makemie's beginnings in and around the Wicomico River area.

Wicomico Presbyterian Church is one of the oldest Presbyterian Churches in North America, established in 1683. The first three church buildings were located on sites west of Salisbury, initially on a site in the vicinity of Upper Ferry and then on two parcels of land along Rockawalkin Creek. The congregation remained at the second Rockawalkin site until the early 19th century when it was decided that a town church would be much more convenient to a growing congregation in Salisbury. In 1830 a single-story, gable-from frame building was erected on a lot donated by Mrs. Sarah Huston of Poplar Hill. The initial town church stood near the intersection Poplar Hill Avenue and Church Street until 1838 when it was moved to the present church site on Broad Street.